Early neuronal pathology that occurs prior to the emergence of histopathology and cognitive decline in Alzheimer’s disease.

Unraveling the mechanisms of synaptic degeneration in Parkinson’s disease and aging, and leveraging this knowledge to bring meaningful relief to those affected.

Unraveling sex differences throughout aging and Alzheimer’s disease with an emphasis on mood disorders.

Dissecting neural circuitry changes across whole brain networks in Alzheimer’s disease to create targeted therapeutics for men and women.

Use of gene transfer vectors to investigate specific gene functions in the brain as it relates to Alzheimer’s disease.

Recruitment of adult endogenous stem cells to generate replacement neurons for brain repair.

Recruitment of adult endogenous stem cells to overcome impaired wound healing characteristic of diabetes.

Identification of dysregulated molecular pathways that lead to progressive neurodegeneration in Parkinson’s disease and dementias.

Identification of diagnostic, progression and stratification RNA biomarkers in blood for Parkinson’s disease.